Ribonucleic Acid (RNA) is a crucial biomolecule involved in genetic information transfer and protein synthesis. Unlike DNA, RNA is typically single-stranded and participates in diverse cellular processes.
RNA Splicing: Biological Mechanisms and Research Advances RNA splicing, a central process in eukaryotic gene expression, ensures accurate genetic information transfer by removing introns and joining exons in precursor mRNA. This highly regulated mechanism profoundly impacts basic biology, medicine, …
RNAScan-RNA Bioinformatics Tools: A Comprehensive Overview RNA scanning tools are pivotal for decoding RNA functions, structures, and interactions across basic sequence analysis to complex functional predictions. This systematic review categorizes tools by functionality, technical principles, repres…
Watson-Crick Base Pairing in RNA Sequence-Specific Tools Watson-Crick base pairing (A-U/T and G-C) underpins RNA secondary structure stability and sequence specificity. This analysis explores how RNA tools leverage Watson-Crick interactions to achieve sequence-specific recognition and functional reg…
RNAmod and Multi-Omics Integration: From Technological Convergence to Systems Biology Revolution As an innovative tool in RNA epitranscriptomics, RNAmod (RNA Modification Analysis Platform) is redefining the boundaries of multi-omics integration through its unique multimodal data analysis capabiliti…
RNAmod: A Comprehensive Analysis Definition and Core Concept RNAmod is an integrated analysis platform designed for studying mRNA modifications (e.g., methylation, pseudouridylation), enabling the annotation, visualization, and comparison of chemical modification sites on RNA molecules. By integrati…
rnaprime.com RNA Prime: A Comprehensive Analysis Definition and Core Concept RNA Prime refers to a precision gene-editing strategy (e.g., Prime Editing) that utilizes prime editing guide RNA (pegRNA) as a "primer" or "template" to write specific edits into target DNA sequences. This approach combine…
RNAi Tools: An In-Depth Analysis RNA interference (RNAi) tools are technologies and reagents that use small RNA molecules (e.g., siRNA, shRNA) to specifically silence target gene expression. Widely applied in functional genomics, drug development, and disease therapy research, their core mechanism r…
I. RNA Therapeutics: From Vaccines to Precision Medicine mRNA Vaccines & Self-Amplifying RNA (saRNA) Infectious Disease Vaccines: By 2025, multiple mRNA and saRNA vaccines are approved globally. Moderna and BioNTech’s personalized cancer vaccines (e.g., BNT122) reach Phase III trials, targetin…
Velo mRNA refers to mRNA Velocity, a dynamic analysis technique in single-cell RNA sequencing (scRNA-seq) that predicts future trends in gene expression, revealing directions of cell differentiation, development, or disease progression. Below are its key components: 1. Definition and Principle Cor…
Modified RNA: Definition and Key Insights Modified RNA refers to RNA molecules chemically or biologically altered from their natural state to enhance stability, functionality, or regulatory capacity. These modifications are revolutionizing biomedical research, therapeutics, and biotechnology. Below …