CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a revolutionary gene-editing technology derived from a natural bacterial immune system.
Key points:
Uses a guide RNA to direct the Cas9 protein to cut specific DNA sequences.
Allows precise insertion, deletion, or modification of genes.
Applications: curing genetic diseases, improving crops, biomedical research.
Nobel Prize in Chemistry (2020) awarded to Doudna & Charpentier for its discovery.
It’s faster, cheaper, and more accurate than older gene-editing methods.
Advances in Exon Editing for Hemophilia, Spinal Muscular Atrophy, and Cancer Therapy (As of May 2025) I. Spinal Muscular Atrophy (SMA): Restoring SMN Protein Expression 1. Precision Repair of SMN2 Exon 7 Base Editing: A-to-G editing at the SMN2 exon 7 C6T mutation increases splicing efficiency to 99…
Latest Advances in Lipid Nanoparticles (lnpdelivery) for Gene Editing and Cancer Immunotherapy (As of May 2025) I. LNP-Driven CRISPR-Cas9 Delivery in Gene Editing 1. Targeting PLK1 in Glioblastoma Technology: Amino-ionizable lipid LNPs encapsulate Cas9 mRNA and sgRNA (targeting PLK1), achieving 70% …
Advances in Limb Rehabilitation and Health: Multimodal Integration and Personalized Medical Revolution (As of May 2025) I. Breakthroughs in Intelligent Rehabilitation Robotics 1. Human-Machine Adaptive Systems Lower Limb Rehabilitation Robot (Chinese Academy of Sciences): Uses cantilever force senso…
Contraindications of COVID-19 Antiviral Therapies: A Comprehensive Analysis (As of May 2025) I. Key Contraindications of Major Antivirals 1. Paxlovid (Nirmatrelvir/Ritonavir) Absolute Contraindications: Hypersensitivity to nirmatrelvir or ritonavir (e.g., Stevens-Johnson syndrome, toxic epidermal ne…
Comprehensive Analysis of SARS-CoV-2 Variants and Emerging Treatments (As of May 2025) I. Key Variants and Epidemiological Features 1. Dominant Circulating Variants XBB.1.5 ("Kraken"): Transmissibility: WHO designates it as the most transmissible Omicron subvariant, with a 3–5x higher R0 than the an…
Comparative Analysis: Genetic Technologies vs. Traditional Methods for Hair Loss Treatment (As of May 2025) I. Limitations of Traditional Methods 1. Pharmacological Therapies Minoxidil & Finasteride: Efficacy: Minoxidil (topical/oral) delays progression of androgenetic alopecia (AGA) and alopeci…
Timeframe Analysis of Genetic Technologies for Hair Loss Treatment I. CRISPR-Based Gene Editing 1. Short-Term Effects (3–6 months) Androgen Receptor (AR) Gene Regulation: CRISPR-mediated reduction of AR sensitivity to DHT slows follicle miniaturization. Preclinical data show halted follicle degenera…
Advances in Genetic Technologies for Hair Loss Prevention and Treatment (As of May 2025) I. Breakthrough Applications of Gene Editing Technologies 1. CRISPR-Cas9 Precision Targeting Androgen Receptor (AR) Gene Regulation: CRISPR editing reduces AR gene sensitivity to dihydrotestosterone (DHT), delay…
Cutting-Edge Applications of Modified RNA: Advancements in Gene Editing and Vaccine Development (Updated 2025) I. Revolutionary Breakthroughs in Gene Editing Assistance Modified RNA is redefining gene therapy by enhancing the efficiency, specificity, and delivery precision of CRISPR systems: 1. CRIS…
Advances in AI-Powered Gene Editing : Optimizing Target Selection, Off-Target Prediction, and Repair Template Design (As of May 2025) I. Intelligent Breakthroughs in Target Selection AIGenEdit redefines gene-editing efficiency and precision through multimodal data fusion and deep learning frameworks…