Gene

Gene

U.S. Tariffs Transform Global Genomics Supply Chains

Multidimensional Impacts and Opportunities of U.S. Tariffs and Trade Conflicts on the Global Genomics Sector I. Core Impacts: The Threefold Fragmentation of the Global Genomics Supply Chain 1. Technological and Supply Chain "Hard Decoupling" Surge in Equipment and Reagent Costs: U.S. tariffs on Chinese gene sequencers and mass spectrometers have led to an average cost increase for imports. Chinese countermeasures, such as higher tariffs on bioreactors, further elevate production costs for domest…

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2025年4月13日
Gene / Rna

2025 RNA Technologies: Innovations in Medicine

I. RNA Therapeutics: From Vaccines to Precision Medicine mRNA Vaccines & Self-Amplifying RNA (saRNA) Infectious Disease Vaccines: By 2025, multiple mRNA and saRNA vaccines are approved globally. Moderna and BioNTech’s personalized cancer vaccines (e.g., BNT122) reach Phase III trials, targeting tumor neoantigens to activate T-cell immunity. Technical Enhancements: Pseudouridine (Ψ) and 5' cap modifications (e.g., ARCA) reduce immunogenicity and extend protein expression. saRNA leverages vira…

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2025年4月12日
Gene / mRNA / SYN

Synth mRNA-SynthmRNA

Synth mRNA: In-Depth Analysis Synth mRNA (Synthetic mRNA) refers to artificially engineered messenger RNA molecules created via biochemical or genetic technologies. Its primary goals are to mimic or enhance natural mRNA functions while introducing novel properties—such as improved stability, controlled translation efficiency, or immune evasion—through chemical modifications or sequence design. Below is a comprehensive breakdown of its principles, applications, and challenges: 1. Definition …

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2025年4月11日
Gene / mRNA

mRNA Speed‌-mRNASpeed‌

mRNA Speed: A Concise Overview mRNA Speed (or mRNA Velocity) is an analytical technique in single-cell RNA sequencing (scRNA-seq) that quantifies dynamic changes in gene expression rates and predicts future directions of cellular state transitions. Below are its key components: 1. Definition and Principle Core Concept: Compares the ratio of unspliced pre-mRNA (newly transcribed, immature RNA) to spliced mature mRNA to infer activation or suppression rates …

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2025年4月11日
Gene / mRNA

mRNA Velocity-VelomRNA

Velo mRNA: A Concise Overview Velo mRNA refers to mRNA Velocity, a dynamic analysis technique in single-cell RNA sequencing (scRNA-seq) that predicts future trends in gene expression, revealing directions of cell differentiation, development, or disease progression. Below are its key components: 1. Definition and Principle Core Concept: Compares the ratio of unspliced pre-mRNA (newly transcribed, immature) to spliced mature mRNA to infer activation or suppression of gene expression. Hi…

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2025年4月11日
Gene / Rna

Modified RNA-ModifiedRNA

Modified RNA: Definition and Key Insights Modified RNA refers to RNA molecules chemically or biologically altered from their natural state to enhance stability, functionality, or regulatory capacity. These modifications are revolutionizing biomedical research, therapeutics, and biotechnology. Below is a detailed breakdown of its principles, applications, and innovations: 1. Core Techniques Chemical Modifications Methylation: Addition of methyl groups (e.g., m⁶A, m¹A) to bases or ribose suga…

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2025年4月11日
Gene / mRNA

mRNA Velocity-mRNAVelocity

In-Depth Analysis of mRNA Velocity mRNA Velocity is an analytical method based on single-cell RNA sequencing (scRNA-seq) data. By quantifying the dynamic ratio of unspliced (pre-mRNA with introns) to spliced (mature mRNA) transcripts, it predicts future gene expression states of cells, inferring directional changes in differentiation, development, or disease progression. Its core objective is to reveal dynamic trajectories of cellular states rather than merely …

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2025年4月11日
BIO / Gene

BioAI Genome-BioAIGenome

BioAI Genome: Definition and Core Principles BioAI Genome represents the intersection of Biological Artificial Intelligence (BioAI) and Genomics, focusing on the use of AI technologies to analyze, predict, design, and engineer genomic data. This field aims to achieve a deeper understanding of biological systems and drive innovation in applications such as precision medicine, synthetic biology, and drug discovery. Its primary goal is to leverage AI algorithms to process vast g…

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2025年4月10日
RNA Tools-RNATools
rnatools.com
Gene / Rna

RNA Tools-RNATools

RNA Tools: In-Depth Analysis and Classification (2025 Edition) RNA Tools encompasses a set of techniques and methods in molecular biology, genetic engineering, and biomedicine for studying, making, and utilizing RNA molecules. These tools range from basic research to clinical applications for RNA synthesis, editing, detection, analysis, and functional regulation. The following is a systematic breakdown of their technical principles, applications, and interdisciplinary intersections. 1. Core defi…

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2025年4月10日
Gene / Rna

RNA enzymes-RNAenzymes

Comprehensive Guide to RNA Enzymes: Classification and Mechanisms RNA enzymes are biomacromolecules with catalytic functions, directly involved in or regulating RNA-related biochemical reactions. They are broadly classified into two categories based on molecular composition and activity: I. Ribozymes: Catalytic RNA Molecules Ribozymes are RNA molecules that catalyze specific biochemical reactions through unique three-dimensional structures, challenging the traditional notion that all enzymes are…

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2025年4月10日