Contraindications of COVID-19 Antiviral Therapies: A Comprehensive Analysis (As of May 2025) I. Key Contraindications of Major Antivirals 1. Paxlovid (Nirmatrelvir/Ritonavir) Absolute Contraindications: Hypersensitivity to nirmatrelvir or ritonavir (e.g., Stevens-Johnson syndrome, toxic epidermal ne…
Comprehensive Analysis of SARS-CoV-2 Variants and Emerging Treatments (As of May 2025) I. Key Variants and Epidemiological Features 1. Dominant Circulating Variants XBB.1.5 ("Kraken"): Transmissibility: WHO designates it as the most transmissible Omicron subvariant, with a 3–5x higher R0 than the an…
Integrating Viral Vector Technologies with Artificial Intelligence: Key Case Studies (Comprehensive Review as of May 2025) The convergence of viral vector technologies and artificial intelligence (AI) is revolutionizing gene therapy, vaccine development, and precision medicine. By leveraging AI-driv…
Splice Genes in Protein Diversity and Tissue-Specific Regulation: Advances and Applications I. Biological Basis of Alternative Splicing and Protein Diversity 1. Prevalence and Molecular Mechanisms Alternative splicing, a central post-transcriptional regulatory mechanism, generates multiple mRNA isof…
Strategies and Recent Advances in Viral Gene-Based Disease Prevention The unique biological properties of viral genes—such as high infectivity, target specificity, and programmability—have revolutionized disease prevention. By engineering viral vectors or leveraging viral genome characteristics, sci…
The Research Significance of Viral Genes in Medical Applications, Gene Therapy, Evolution, and Epidemiology I. Core Roles of Viral Genes in Medical Applications 1. Breakthroughs in Gene Therapy Vectors Genetically engineered viruses serve as efficient gene delivery tools, leveraging their natural in…
SynBio V: Engineering Viral Vectors for mRNA Vaccine Design and Production Integrating Viral Delivery Systems with Synthetic Biology Tools 1. Technological Foundations: Synthetic Biology Reengineering of Viral Vectors Viral vectors, as core mRNA delivery tools, require synthetic biology modification…
Vector Vaccines: A Cornerstone Tool Against Emerging Infections, Cancer, and Genetic Diseases Core Mechanisms and Technical Principles Vector vaccines use engineered viruses or bacteria as delivery vehicles to introduce foreign antigen genes into host cells, triggering specific immune responses. Key…
CRISPRFlow: Integrated Applications in Infectious Disease Diagnosis, Cancer Screening, and Genetic Disorder Analysis CRISPR technology has evolved from a gene-editing tool into a comprehensive solution spanning disease diagnosis, therapeutic development, and precision medicine. Its core strengths—hi…
ViralVectorAI: The Role and Future of AI-Driven Viral Vector Technology in Gene Editing The integration of AI and viral vector technology is revolutionizing gene editing, driving advancements in precision, intelligence, and industrial scalability. By optimizing vector design, predicting editing outc…